Physiologically based pharmacokinetic modeling to predict the effect of genetic variability on drug exposure: Dr Cleavon Cloete

Dr Cleavon Cloete completed his undergraduate studies at the University of Stellenbosch and was awarded a BSc in molecular biology and biotechnology with a specialisation in biochemistry and microbiology. He subsequently completed a BMedSc Honours degree at the University of Cape Town specialising in clinical pharmacology, with his project focusing on the ADME properties and cytochrome P450 (CYP) mediated metabolism of a potential novel malaria drug. In 2019, he completed his master’s studies in clinical pharmacology at the University of Cape Town. His project work was based on the development and partial validation of bioanalytical methods for the measurement of CYP activity in human liver microsomes with the use of probe substrates. He recently completed his PhD in the department of chemistry at the University of Cape Town, with his project entitled “In vitro metabolism studies to inform physiologically based pharmacokinetic modelling of mefloquine, ritonavir and proguanil”.